翻訳と辞書 Words near each other ・ Yêndum ・ Yêu một người – Sống bên một người ・ YWCA Site ・ YWCA USA ・ YWCA Youngstown ・ YWCA, Phillis Wheatley Branch ・ YWCA-Rolling Bay Route ・ YWCA-YMCA Guides and Scouts of Norway ・ YWCA-YMCA of Sweden ・ YWHAB ・ YWHAE ・ YWHAG ・ YWHAH ・ YWHAQ ・ YWHAZ ・ YWTD domain of low-density lipoprotein receptor ・ YX ・ YX Energi ・ YXA ・ Yxaiio ・ Yxlan ・ YXORP ・ Yxskaftkälen ・ Yxsmedsgränd ・ Yxta Maya Murray ・ Yxtaholm Castle ・ YXY ・ Yxygodes ・ YY ・ YY (social network) Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク YWTD domain of low-density lipoprotein receptor ： ウィキペディア英語版 YWTD domain of low-density lipoprotein receptor The low-density lipoprotein receptor (LDLR) regulates cholesterol homeostasis in mammalian cells. LDLR binds cholesterol-carrying LDL, associates with clathrin-coated pits, and is internalized into acidic endosomes where it separates from its ligand. The ligand is degraded in lysosomes, while the receptor returns to the cell surface. The LDLR has several domains. The ligand-binding domain contains seven LDL receptor class A repeats, each with three disulphide bonds and a coordinated Ca2+ ion. The second conserved region contains two EGF repeats, followed by six YWTD or LDL receptor class B repeats and another EGF repeat. This conserved region is critical for ligand release and recycling of the receptor. The structure of the six YWTD repeats of LDL receptor have been solved. The six YWTD repeats together fold into a six-bladed beta-propeller. Each blade of the propeller consists of four antiparallel beta-strands; the innermost strand of each blade is labeled 1 and the outermost strand, 4. The sequence repeats are offset with respect to the blades of the propeller, such that any given 40-residue YWTD repeat spans strands 24 of one propeller blade and strand 1 of the subsequent blade. This offset ensures circularization of the propeller because the last strand of the final sequence repeat acts as an innermost strand 1 of the blade that harbors strands 24 from the first sequence repeat. The repeat is found in a variety of proteins that include, vitellogenin receptor from ''Drosophila melanogaster'', low-density lipoprotein (LDL) receptor, preproepidermal growth factor, and nidogen (entactin). ==References== 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「YWTD domain of low-density lipoprotein receptor」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.